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KMID : 1123920030170020542
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 2 p.542 ~ p.548
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Antioxidant Activities of Glycyrrhizin and its Effect on Renal Expression of Na,K-ATPase in Gentamicin-induced Acute Renal Failure Rats
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Sohn Eun-Jin
Kang Dae-Gill
Lee An-Sook
Lee Yun-Mi
Yin Ming-Hao
Yeum Kee-Bok
Noh Suk-Yeon
Lee Ho-Sub
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Abstract
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The present study was aimed to investigate whether glycyrrhizin, which is the major component of Glycyrrhiza uralensis, has an antioxidant effect and regulatory effect on Na,K-ATPase in gentamicin-induced acute renal failure (ARF) rats . It is well known that reactive oxygen species (ROS), such as superoxide anion and hydroxyl radical, are main pathophysiological factor in gentamicin-induced ARF. Glycyrrhizin showed potent in vitro antioxidant activity, especially superoxide scavenging activity, in a dose-dependent manner. Plasma lipid peroxide level was restored to normal level by oral administration of glycyrrhizin (200 mg/kg) in the gentamicin-induced ARF rats. The expression of Na,K-ATPase α1 subunit was restored in the gentamicin-induced ARF rats by administration of glycyrrhizin, whereas β1 subunit was not restored. The renal functional parameters including urine volume, cleatinine clearance, urine osmolality, solute-free water reabroption were also partially restored in gentamicin-ARF rats by administration of glycyrrhizin. Taken together, the amelioration of renal functions and the expression of sodium pump by administration of glycyrrhizin in the gentamicin-induced ARF was appear to be mediated by the scavenging of ROS.
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KEYWORD
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glycyrrhizin, Na, K-ATPase, gentamicin-ARF rats, reactive oxygen species
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